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A frequently observed prerequisite for the onset of cancer is genomic instability which is affected by aberrant methylation patterns of the genome (Negrini et al., 2010

Specifically, the relatively small sample size, the unbalanced male/female ratio (with a higher number of males in two of the three cohorts), and the short intervention period constrained our ability to assess the long-term effects of the Sucrosomial B12 formulation