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All three routes improved MCL healing, supporting the clinical observation that BPC-157 retains activity orally and topically (a property unusual among peptides), although effect sizes varied by route

When to Use Caution With Glutathione Supplementation Important Note: If you experience increased fatigue, nausea, joint or muscle aches, or any other adverse reaction when taking glutathione, seek the attention of a functional medicine-trained dietitian or physician

Nature , 593 (7860), 586590

However, for researchers, it's a key variable to monitor, as it can temporarily affect weight and measurements

Individuals with cystinuria or homocystinuria, those on chemotherapy, or taking certain medications should consult a provider before supplementing, as glutathione may interact with specific treatments