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3094 In Re: Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs) Products Liability Litigation in the Eastern District of Pennsylvania to centralize lawsuits alleging that manufacturers failed to warn patients and physicians about serious health risks associated with GLP-1 drugs like Ozempic, Wegovy, and Rybelsus
5, 1116, 18, 23, 25, 26 in the associated source data file
It is a C-terminally amidated linear polypeptide with a 37-amino-acid main chain (single L-enantiomer) in which the native amylin disulfide is replaced by a methylene thioacetal bridge between Cys2 and Cys7 to enhance chemical stability, and Lys26 is acylated with a side chain of two -glutamate residues and a saturated C20 fatty diacid that supports a long, once-weekly-compatible half-life
