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[1] Monitoring recommendations for patients using both medications include: Regular blood glucose testing particularly post-lunch and early evening when morning prednisolone is used Consider action if readings are persistently above 12 mmol/L (with individualisation based on your care plan) HbA1c measurement every 3 months for patients with diabetes or prediabetes Fasting glucose checks if not previously diabetic, particularly during corticosteroid therapy Symptom awareness for hyperglycaemia (increased thirst, frequent urination, fatigue, blurred vision) Patients with established diabetes may require adjustments to their glucose-lowering regimen whilst on prednisolone

That means some things may not work as well, or may start building up in ways you dont expect

A GLP-1 medication works best as one tool within a broader midlife care plan