and c) irregular dietary patterns), reduced bioavailability (impairment of the intrinsic factor-mediated absorption pathway, often due to the widespread and prolonged use of proton pump inhibitors), and malabsorption syndromes
Counts under 50,000/L are moderate, under 20,000/L are severe, and under 10,000/L are very severe
It may also enhance the activity of certain immune cells, which may ward off viruses and chronic disease such as cancer, according to a 2020 review in the medical journal, Nature (2)
When NNMT activity is inhibited, these methyl donors become available for other methylation reactions in the body
This can be problematic for people with certain health conditions or older adults whose digestive efficiency may be compromised