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Effects on neurotransmitter systems may support the mood, cognitive, and sleep dysregulation that are near-universal in long COVID

In people who are underweight or have lost a significant amount of weight quickly, your body suppresses your reproductive hormones leading to hypothalamic amenorrhea (absent periods)

Redox Biol 36:101679 Albano GD, Gagliardo RP, Montalbano AM, Profita M (2022) Overview of the mechanisms of oxidative stress: impact in inflammation of the airway diseases

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Separating doses by at least 2 hours and using injectable naltrexone (if available) may mitigate this concern