In addition, hypoxia signaling has a significant impact on the Notch1 and HIF-1 signaling pathways, which influence each other and participate in physiological and pathological processes related to hypoxia, such as angiogenesis and tumor metastasis [509, 510]
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In addition, curcumin has low solubility, rapid metabolism, and is difficult to reach effective concentrations in the human body, which is also an urgent problem to be solved
Kauvar LM, Morgan AS, Sanderson PE and Henner WD