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Originally characterized at the University of Florida by the Stephen ORahilly and Robert Kraft groups, the compound has been studied in preclinical research for body composition, adipose tissue lipolysis, glucose homeostasis, skeletal muscle aging, and metabolic disease endpoints

May 2018;297(5):1081-1088

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Specific triggers of ferroptosis, such as erastin, may promote this process by affecting the cystine/glutamate antiporter system or by inhibiting the activity of GSH peroxidase (178)