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Editorial note: No randomized controlled trial has yet tested resistance training as a counter-measure specifically to GLP-1-induced lean-mass loss
This contrasts with conventional T2D therapies like sulphonylureas, insulin and thiazolidinediones, which induce weight gain as a by-product of treatment
It is primarily synthesized in the liver by the transsulfuration pathway and exported to provide precursors for in situ GSH synthesis by other tissues
announced the decision to discontinue the development of Danuglipron (PF-06882961), an oral GLP-1 receptor agonist previously investigated for chronic weight management
Additionally, treatment with 10 nM E2, for 7 days, stimulated differentiation to the neuronal lineage, and inhibited differentiation to astrocytes (Zhang et al., 2019)
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