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What was found in both studies is that the drug ixekizumab, the biologic, the anti-IL-17 for psoriasis, actually worked better in terms of its effect on skin and its effect on joints when it was combined with the GLP-1 drug tirzepatide compared to ixekizumab alone

[10] also found that metformin at doses exhibiting GLP-1-increasing effects exerted no effect on plasma DPP-4 activity in mice

Neuron 30:399410

GLP-1s help restore proper signaling in the brain and gut, which creates a more natural, controlled approach to eating and weight regulation

Skin Sensitivity: Mild irritation or warmth may occur due to the absorption-enhanced base