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The net cost comparison depends heavily on bioavailability

To measure NMDA-induced inward current from GLP-1-receptor-positive neurons, we used magnesium-free aCSF (126 mM NaCl, 2.8 mM KCl, 2.5 mM CaCl 2 , 1.25 mM NaH 2 PO 4 , 26 mM NaHCO 3 and 5 mM glucose) containing 10 M CNQX and 100 M picrotoxin

Next-generation candidates like Novos CagriSema or Amgens MariTide will need to demonstrate meaningful advantages in cardiovascular outcomes, NASH or metabolic disease to command better pricing

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