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When NAD levels decline, it results in a decrease in cellular energy, which can also be described as mitochondrial dysfunction a condition that is implicated in most chronic illnesses, including diabetes, autoimmune disorders, Alzheimers, multiple sclerosis and many more

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This may be related to the higher creatinine concentration and more muscle mass in men (34)

However, although serum IGF levels are closely associated with tumor progression, IGF also plays an important regulatory role in normal life activities, such as maintaining skeletal muscle growth and development, islet proliferation and cell metabolism