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if too lipophilic, the drug is not soluble enough to cross the water layer adjacent to the cell

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This fact is relevant as transgenic mice overexpressing IGFBP-2 were resistant to developing obesity when fed with high fat diet [174], suggesting that this molecule could have a direct effect on preadipocyte differentiation

Consequently, IGF-1 LR3 has improved potency and metabolic stability [5]