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Two mutations occurred in the 3 untranslated region of an alternative splice form of HGF, while the third mutation altered splicing by affecting the relative strengths of the spliced forms of HGF gene

This antioxidant activity is vital because excessive ROS can impair mitochondrial function, leading to oxidative stress and affecting the energy production of neurons and glial cells, potentially causing migraine headaches ( Vitamin B2 deficiency disrupts intermediary metabolism, potentially impairing energy production via the ETC, which is mainly concerned for the nervous system, given its high energy demands, and also can lead to disorders, such as migraine, because of energy failure, alongside overproduction of ROS (47)

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Ranjan A, Ramachandran S, Gupta N, Kaushik I, Wright S, Srivastava S, et al

Lactate: the mediator of metabolism and immunosuppression