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Mechanistically, HDAC inhibition upregulates expression of multiple genes that are fundamental to protein phosphorylation and ubiquitination, including Ube2K, Ubqln, Ube2e3, Usp28, Sumo2 , as well as the genes encoding components of the inhibitor of B kinase (IKK) complex (Jia et al., 2012)
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Helps with symptoms of premenstrual syndrome (PMS) including breast pain and depression Helps with perimenopause mood swings, which are a result of high estrogen levels, hot flashes, and night sweats
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