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High generation of reactive oxygen species from neutrophils in patients with severe COVID-19

They mostly occur as isolated effects and are considered by the pathologist in distinguishing background hepatic lesions versus xenobiotic-induced lesions that occur in rodent preclinical toxicity studies

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Its ability to stimulate collagen synthesis, glycosaminoglycan production, and balanced tissue remodeling is supported by multiple studies

Caroline Apovian, MD, Harvard Medical School The exact mechanism isn't fully understood