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Gong et al., 2024), result in DNA lesion formation and thiol group oxidation

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In TRIUMPH-4, participants with obesity and knee osteoarthritis taking retatrutide 12 mg lost ~28.7% of body weight (~71 lbs at 68 weeks) and saw substantial improvements in pain and function: WOMAC pain scores reduced by 4.5 points (75.8%) Meaningful gains in physical function, with many patients essentially free of knee pain by study end If these results are confirmed in broader use, were not just talking about weight loss drugs anymorewere talking about disease-modifying therapies that simultaneously target obesity, pain, mobility, and downstream CV risk

Skin levels can saturate after repeated application