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Thus, in a nutshell, it is possible that the initial DNA damage that predisposes melanocytes to malignant transformation and cytogenetic alterations that later promote actual malignant transformation of the initially transformed melanocytes may be driven by dysregulation in melanin biosynthesis and by the increased cellular content of melanin [10]
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By the time Samols returned to the Royal Free Hospital in 1964, many researchers had begun to intensify their efforts to characterise, identify and purify substances in the intestine released in response to eating that helped to stimulate insulin secretion
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