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The pill contains an absorption ingredient that can pass into breast milk, so it is not recommended during breastfeeding
The NHS lists injection-site pain and itching as common and self-limiting
Starting weight loss therapy with uncontrolled hypothyroidism may: Confound assessment of treatment efficacy Complicate symptom attribution (fatigue, constipation overlap) Necessitate multiple medication adjustments simultaneously Practically speaking, patients may benefit from demonstrating stable thyroid function on consistent levothyroxine dosing before adding weight loss medications, though this is not a strict requirement
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The strategy reflects a broader shift in MASH drug development from treating fibrosis alone toward addressing the underlying metabolic dysfunction that drives inflammation and liver injury
