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Panczenko-Kresowska B, Ziemlaski S, Rudnicki S, Wojtulewicz L, Przepirka M

[28] [29] Before starting GLP-1 therapy, your healthcare provider will: Review your complete medical history, including thyroid disease status Ensure thyroid function is optimised Assess for any contraindications Discuss the benefits and risks specific to your situation With appropriate patient selection and monitoring, GLP-1 receptor agonists can be safely prescribed to individuals with Hashimoto's disease when the clinical benefits outweigh potential risks

GLP-1 agonists mimic a natural hormone called glucagon-like peptide-1

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And in short that came out a few years after that STEP 1 trial what we did for the very first time is take individuals with obesity and pre-existing cardiovascular disease, like a prior stroke, prior heart attack, or peripheral arterial disease, called PAD, and they're on maximal therapy for their cardiovascular disease or stroke, and then randomized them on top of that to either semaglutide or placebo