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doi: 10.1016/j.neuropharm.2013.08.005 45 KimSMoonMParkS
The randomized, double-blind study demonstrated statistically significant improvements in blood sugar control at all tested doses, along with meaningful weight loss outcomes at the 14 mg dose compared to the placebo group. High-dose oral semaglutide has since demonstrated more substantial results
Together these modifications reduce IGFBP binding affinity by approximately 1,000-fold compared to native IGF-1 while preserving IGF-1 receptor (IGF1R) binding
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M., Dewhirst, M
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