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The gastrointestinal tract and the brain are involved in a complex bidirectional communication, which is mediated by the endocrine, immune and neural pathways, involving a plethora of different neurotransmitters, cytokines and peptide hormones [98]

Clinical trials have shown that patients using semaglutide lose an average of 14.9% of their body weight over 68 weeks

On a bell curve, an increase that produces less effect is ambiguous: you cannot tell whether you are below the peak or past it

Jorsal A, Wiggers H, Holmager P, Nilsson B, Nielsen R, Boesgaard TW, Kumme A, Mller JE, Videbk L, Kistorp C

Neuron 97, 12681283.E6.10.1016/j.neuron.2018.02.027 253 NiwaJ.YamadaS.IshigakiS.SoneJ.TakahashiM.KatsunoM.et al