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The hormone's combined central and peripheral effects are attributable to its capacity to traverse the bloodbrain barrier, facilitating extensive metabolic control (Prete et al
Bayr H, Anthonymuthu TS, Tyurina YY, Patel SJ, Amoscato AA, Lamade AM, et al
Clinical profile and treatment patterns in individuals with type 2 diabetes and chronic kidney disease who initiate a GLP-1 receptor agonist: a multinational cohort study
Additionally, semaglutide has been associated with an increased risk of certain thyroid tumors in animal studies, although it is unclear if this risk translates to humans
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