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(PubMed) Keith M, Mazer CD, Mikhail P, Jeejeebhoy F, Briet F, Errett L

Sikiric P, Seiwerth S, Rucman R, Turkovic B, Stancic Rokotov D, Brcic L, Sever M, Klicek R, Radic B, Drmic D, Ilic S

When combined with the electricity costs for the backwash pumps, metering pumps, and air compressors, this portion of the expense amounts to approximately 10% to 20% of the chemical reagent cost

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Extended Half-Life and Sustained Receptor Engagement The 13-amino acid N-terminal extension and Arg3 substitution reduce IGFBP binding by 7080%, extending the effective half-life from approximately 10 minutes to 2030 hours in rodent plasma resulting in prolonged IGF-1R activation in cell culture and animal models that is not achievable with native IGF-1 or shorter analogues