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they act on growth hormone and incretin pathways respectively, and their use outside approved clinical trials is unsupported by robust clinical evidence
The FDA cleared orforglipron for chronic weight management in adults with obesity, or overweight with at least one weight-related comorbidity, based on the ATTAIN clinical program which showed placebo-adjusted weight loss of 7.5% to 11.2% in non-diabetics (ATTAIN-1) and 5.1% to 9.6% in diabetics at different doses, along with the expected glycaemic benefits (ATTAIN-2)
Full disclaimer 1.Ipamorelin is a synthetic pentapeptide growth hormone secretagogue that selectively stimulates GH release from the pituitary by activating the ghrelin receptor (GHSR)
The same recommendation to weigh breastfeeding benefits against clinical need
Long-term use might be necessary for sustained effects, which requires a careful look at the benefits versus the risks
