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24 With respect to this, the negative association between frequency of the cSHMT -C1420T variant and latitude documented in this study may indicate that activity of the de novo thymidylate synthesis pathway is increasingly impaired in populations exposed to higher UVR, but the burden of this variant is unclear due to mSHMT likely maintaining cSHMT activity in such cases

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By binding to receptors on immune cells, VIP suppresses the activity of inflammatory signaling molecules and modulates the behavior of immune cells, including T cells and macrophages (7)