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VEGFR2 activation triggers downstream Akt phosphorylation and endothelial nitric oxide synthase signaling, raising nitric oxide output and supporting new vessel formation
Was the evidence cellular, animal or human
10.1002/ptr.8217 Summary Keywords IgA nephropathy, ROS, extracellular matrix, Nrf-2, luteolin (LUT) Citation Liang D-Y, Cong S-H, Li L-H, Yi Q-Q, Tang L-P and Cao L-O (2025) Luteolin delays the progression of IgA nephropathy by attenuating inflammation, oxidative stress and reducing extracellular matrix accumulation through activating the Nrf-2/HO-1 pathway
However, the absence of solid human clinical trial data means these therapies should be approached with scientific caution and humility