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They concluded that while GHK-Cu does demonstrate anti-wrinkle effects in cellular studies, "there is a surprising absence of clinical studies using them." The review identified skin permeation as the central challenge: GHK's high aqueous solubility and low partition coefficient work against transdermal absorption
Key Takeaway: GHK-Cu, BPC-157, retinol, and Vitamin C occupy different points in the regenerative and dermatological-research landscape
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Academic Press
The 10 mg dose produced 19.5%
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