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This study, by far, was the most extensive evaluation of CV risks associated with metformin use

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The study in Molecular Nutrition and Food Research demonstrated that nicotinamide supplementation in mice on a high-fat diet reduced body weight gain, increased energy expenditure, and upregulated genes involved in thermogenesis and fat oxidation, including PPARalpha and PGC1alpha

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Potential therapies may be developed by exploring more therapeutic targets and methods