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In the LEAN trial, a small phase 2b trial, treatment with 1.8 mg/day liraglutide resulted in a histologic resolution of NASH and a decreased progression of fibrosis [27]
This study was submitted for evaluation by the Ethics Committee on the Use of Animals (CEUA) of UNESC under protocol number 07/2023
It has already been mentioned that empagliflozin is currently being studied as adjunct to GLP1a, as well as tirzepatide
Common drawbacks include nausea, digestive symptoms, fatigue during dose increases, and cost
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