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The standard retatrutide dose schedule is: Weeks 1-4: 1 mg once weekly Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Week 17 onward: 8-12 mg once weekly (maintenance) In the combination context, many researchers find that 8 mg is sufficient for their maintenance dose rather than pushing to 12 mg, because the cagrilintide provides enough additional appetite suppression and satiety to make the extra 4 mg of retatrutide unnecessary
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Your safety protocols should include periodic bloodwork, and B12 should be on that panel
Cagrilintide was initiated at 0.3 mg for the 0.3 mg group, or 0.6 mg for all higher-dose groups and escalated every two weeks until reaching the final dose
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