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Smaller water volumes give a more concentrated solution (fewer units per dose)
A prespecified blinded extension focused on participants with BMIs of 35 or higher showed that those continuing on retatrutide 12 mg up to 104 weeks lost 30.3% of their body weight on average
FDA described insufficient clinical safety information, characterisation concerns and inadequate evidence of effectiveness for its reviewed use
What this means in practice: lower-cost alternatives are coming, but the timeline varies significantly by country, and US patients face a longer wait than most headlines suggest
Researchers want to find out whether retatrutide works equally well for everyone, or if some individuals are likely to benefit more than others
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