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Serious adverse events have not been reported in the preclinical toxicity literature, which found no identifiable lethal dose across four species by Xu 2020

In addition, patients whove undergone gastrointestinal-related surgeries may be at risk of B12 deficiency due to malabsorption

If you are experiencing a medical emergency, call 911.

If you are experiencing any of these symptoms without a clear reason then checking your vitamin B12 levels would be the next appropriate step: How to check for Vitamin B12 Levels Its important to realize that some medical conditions are not appreciated and not taken as seriously as others

TB-500's removal happened in April 2026 after the original nominators withdrew their submissions