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Methods Plasma levels of PGA, kynurenine, and tryptophan were quantified by liquid chromatography-mass spectrometry in cohorts comprising healthy TTR wild-type controls, asymptomatic carriers of the TTR-V30M mutation, and symptomatic patients with TTR-V30M amyloidosis
Reports contain similar claims of GI side effects, particularly in off-label or long-term users
The resulting decrease in thyroid hormones impacts cells throughout the body, causing symptoms such as: Fatigue Weight gain Headaches and migraines Thinning or dry hair, nails, and skin Feeling cold all the time Irregular periods Puffiness or fluid retention Fertility problems Slow digestion and constipation Brain fog Depression Aching muscles and joints Loss of muscle strength and tone These symptoms may be vague early on, but the inflammation can result in an enlarged thyroid (goiter) and thyroid nodules over time
Epidemiology 33 , 563571 (2022)
"But I don't know anyone who actually hits that number and feels like that," he says
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