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Notably, key transcription factors such as SOX2, which promote and maintain the dry characteristics of cancer cells, can upregulate the expression and autocrine activity of IGF-2, and IGF-2 then activates the IGF-1R/AKT signaling pathway to enhance the invasive and stemness characteristics of bladder cancer, forming a vicious cycle (28)
Diuretics (commonly prescribed for hypertension or heart failure) directly increase urine production
Certain bacterial strains stimulate L-cells to produce more GLP-1
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