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In a June 2025 position document, the regulator noted the rise of unauthorized and counterfeit semaglutide products and stated that sterile compounding is a high-risk activity that should generally be reserved for exceptional circumstances, such as a patient-specific need that cannot be met by an approved drug or a true shortage

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Data suggests that the combination therapy results in a smoother, more sustained reduction in gastric emptying compared to monotherapy, leading to a more stable blunting of post-prandial glucose spikes without the compensatory hypoglycaemia often seen in insulin-based interventions

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