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3,4 GLP-1RAs mimic the action of endogenous GLP-1, activating GLP-1R, thereby enhancing insulin secretion, inhibiting glucagon release, delaying gastric emptying, and reducing food intake through central appetite suppression
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doi: 10.1016/S0140-6736(78)92994-X 6 DiakogiannakiEGribbleFMReimannF
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[1] [2] In terms of timeline, early changes in appetite and food intake may be noticed within the first two to four weeks of starting treatment, even at lower starting doses
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