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48% discontinuation among weight loss GLP-1 users 33% discontinuation among diabetes GLP-1 users Discontinuation of GLP-1 therapy is associated with metabolic rebound, including weight regain, rising blood pressure, and worsening glycemic control, undermining both clinical outcomes and the value of initial investment
This was the first GLP-1 agonist to demonstrate cardiovascular benefit
Mild, transient diarrhoea is a recognised and generally manageable side effect of retatrutide
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Why we cap deficits at 15% We recommend a more sustainable weight-loss rate of around 0.5-1kg per week, as research suggests that losing weight faster than this can increase muscle and bone loss
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