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IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms
In a population without specific risk factors for thyroid cancer, the benefits of GLP-1 RAs will largely outweigh the harm. The European Medicines Agency in October 2023 announced that they did not find a causal link between GLP-1s and thyroid cancer after a months-long review
vitamin B6, or the active form, which is pyridoxal-5-phosphate (P5P)
For many patients on the weight-loss medications known as GLP-1s (glucagon-like peptide-1s), such as semaglutide, tirzepatide and liraglutide, the question of when or whether to stop is inevitable
We thank Dr Raymond Thomas (postdoctoral fellow) for published data on brain lipids and Drs Stephan Kahler and Anirudh Saronwala for their insight into propionic metabolism
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