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These observations are more broadly relevant to drug discovery at peptide GPCRs for which ligand acylation is a valid approach to improve pharmacokinetics
* Based on the trial product estimand: estimated efficacy in an idealized scenario in which all patients stayed on treatment and took no other weight loss therapies
Improved glucose regulation: The medication enhances insulin secretion in response to meals and reduces the production of glucagon, a hormone that increases blood sugar levels
In another study treatment with 20nM Ex-4 on rat adipose-derived MSC additionally elevated OPG and RUNX2 protein levels, while reducing osteoclast activity [29]
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