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A lysine at position 28 is switched out for an arginine, which leaves another lysine at position 26 free to be modified with a long fatty-acid/ethylene glyol-like chain, which improves the drugs half-life in the blood even more (by binding to serum albumin)

This is known as receptor desensitization

The main concern with oral contraception and GLP-1 drugs is not harm, but effectiveness

Kaempferol (Progesterone Receptor Modulation) For women in whom progesterone receptor activity is a significant contributor to fibroid growth, kaempferol, a flavonoid found in some plants and foods, has demonstrated progesterone receptor modulatory activity in preclinical studies

Even though each drug has different FDA-approved usages, they are all often used off-label for blood sugar management and weight reduction, regardless of whether thats the individual drugs FDA-approved use case