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While there is no problem with doing so, and we as medical professionals do actually recommend supplements in specific cases, this may not be the most optimal method for B12

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Summary: Retatrutide has no UK marketing authorisation, meaning there is no approved guidance on how to mix it with bacteriostatic water, and self-reconstitution outside a regulated clinical setting is unsafe

However, they should be used in conjunction with a healthy diet and exercise program, rather than as a standalone weight loss method.

The effects of alcohol on ambulatory blood pressure and other cardiovascular risk factors in type 2 diabetes: a randomized intervention