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Characterising how specific amino acid changes in variant receptors alter binding affinity, Gs coupling efficiency, cAMP signalling, and MITF activation in response to MC1R agonist stimulation

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The response of cells to any stress (including cell division and apoptosis) involves changes in thiol content as they are consumed to protect cells via different actions (direct modification/regulation of biomolecules, antioxidativity, detoxification, signal transmission)