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Angiogenesis is an early event in the pathogenesis of RA, which is crucial for the proliferation of synovial tissue and the formation of pannus (105, 106)

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( A and B ) Intracellular cAMP accumulation measured by enzymatic immunoassay in lysates from ( A ) caSMCs and ( B ) mouse and human caECs treated for 10 minutes with 100 nM each of GLP-1(2836), scrambled control, IPE, forskolin, or PBS control ( n = 3/treatment, each in triplicate)