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This compound also induces the expression of thymic stromal lymphopoietin (TSLP) which participates in the induction of an AD-like phenotype (227)

The cryo-EM structures of retatrutide-bound GLP-1R, GIPR and GCGR reveal a combination of conserved peptidereceptor interactions and receptor-specific conformations, particularly in ECL1, that enables retatrutide to execute agonism at multiple receptors

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