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The Satiety and Clinical Adiposity Liraglutide Evidence (SCALE) Obesity and Prediabetes randomized, double-blind, placebo-controlled trial of 3.0 mg of once daily liraglutide achieved a mean 8.4 kg weight loss in patients with obesity without T2DM [7]
When muscle is lost during weight management, it can result in: Decreased metabolic rate Reduced physical strength and endurance Difficulty maintaining weight loss long-term Diminished quality of life and functional capacity For those using medical weight management approaches, these concerns become even more pressing, as the accelerated weight loss can sometimes lead to greater muscle breakdown without proper nutritional support
2010;125(5):e1249-1254
doi:10.1006/abio.1998.2615
Cell 183 , 1627 (2020)
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