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Specifically, beyond the enteroendocrine L-cells of the intestine, GLP-1 is also produced as a neuropeptide by the pre-proglucagon neurons in the brain stem 3

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--- 4 Pharmacokinetics Parameter Detail Absorption Well absorbed orally Bioavailability ~100% Peak Plasma Time 34 hours Half-life ~70 hours (once daily dosing) Metabolism Liver (CYP2D6 & CYP3A4) Excretion Urine (major), feces Long half-life Once daily dosing

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Fraser DA, Thoen J, Bondhus S, Haugen M, Reseland JE, Djoseland O et al