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IGF-1 LR3 Timeline & What to Monitor There is no validated efficacy timeline for IGF-1 LR3 in humans
A simplified reaction is shown below: 2 GSH + H 2 O 2 GSSG + 2 H 2 O Glutathione reductase (GR) changes GSSG back to GSH by using NADPH: GSSG + NADPH + H + 2 GSH + NADP + GPx and GR form the main GSH/GSSG recycling cycle
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The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity
& Schaeffer, J
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