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Qualifying comorbidities include type 2 diabetes, hypertension, dyslipidemia (abnormal cholesterol levels), and obstructive sleep apnea
doi: 10.1126/scitranslmed.aar7047 101 FDA U
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Metabolism of TAM takes place mainly through two main pathways, 4-hydroxylation and N-demethylation, from which TAM is converted to primary metabolites 4-hydroxy-tamoxifen and N-desmethyl-tamoxifen (Klein et al., 2013)
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