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Oral B12 looks cheap, but if your body absorbs very little of each pill because of low stomach acid or a gut condition, much of that spending does not translate into results, and you keep buying bottle after bottle

Anyone with a personal or family history of certain thyroid cancers, pancreatitis, or serious gastrointestinal disease sits outside the comfortable-experimentation zone these compounds occupy, since those conditions appeared in trial exclusion criteria for good reason

For example, a person lacking both Vitamin B12 and folate might have more severe thrombocytopenia

They restore function

The rationale above is mechanism-based community reasoning, not direct combination evidence